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Research on CBD, THC, ITAL Water USA, and other cannabinoids - CBDPhilman

ITAL Water USA is a Cannabis Water for Wellness

italwaterusa.com 

#ital  #cannabiswater  #irie




ITAL Water USA by Suver Nuver Foundation, Hemp Synergistics and CBD Philman.

philman@italwaterusa.com 

#ital  #cannabiswater  #irie



CBD

J Am Pharm Assoc (2003) . Jan-Feb 2020;60(1):253-261. doi: 10.1016/j.japh.2019.11.008. Epub 2019 Dec 19. Use of cannabidiol in anxiety and anxiety-related disorders Jessica W Skelley, Crystal M Deas, Zachary Curren, Jonathan Ennis PMID: 31866386 DOI: 10.1016/j.japh.2019.11.008   ITAL Water USA is a Cannabis Water for Wellness



Curr Pain Headache Rep . 2020 Jan 24;24(2):4. doi: 10.1007/s11916-020-0835-4. The Role of Cannabidiol (CBD) in Chronic Pain Management: An Assessment of Current Evidence Shafik Boyaji 1 2, Justin Merkow 1 2, R Noel M Elman 3, Alan D Kaye 4, R Jason Yong 1 2, Richard D Urman 5 Affiliations expand PMID: 31980957 DOI: 10.1007/s11916-020-0835-4


Bio-Availability

Milar S, Stone N, YatesA, O’Sullivan S. A systematic review of the pharmacokinetics of cannabidiol in humans. Frontiers in Pharma 26 Nov 2018   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275223/ 


Jiang R, Yamaori S, Takeda S, Yamamoto I, Watanabe K. Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes. Life Sciences 89 (2011) 165-170  https://pubmed.ncbi.nlm.nih.gov/21704641/ 

 

Zendulka O, Dovrelova G, Noskova K, Turjap M, SulcovaA, Hanus L, Jurica J. Cannabinoids and Cytochrome P450 Interactions. Curr Drug Metab 2016;17(3):206-26   https://pubmed.ncbi.nlm.nih.gov/26651971/ 


Rajinder K. Bhardwaj, Hartmut Glaeser, Laurent Becquemont, Ulrich Klotz, Suresh K. Gupta and Martin F. Fromm. Piperine. A Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther.August 2002, 302 (2) 645-650   https://pubmed.ncbi.nlm.nih.gov/12130727/


Volak L, Ghirmai S, Cashman J, and Court M. Curcuminoids inhibit multiple human cytochromes P450 (CYP), UDP-glucuronosyltransferase (UGT), and sulfotransferase (SULT) enzymes, while piperine is a relatively selective CYP3A4 inhibitor. Drug Metab Dispos. 2008Aug; 36(8): 1594–1605.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574793/


Ho P C, Saville D J, Coville P F, Wanwimolruk S. Content of CYP3A4 Inhibitors, Naringin, Naringenin and Bergapten in Grapefruit and Grapefruit Juice Products. PharmActa Helv. 2000Apr;74(4):379-85. https://pubmed.ncbi.nlm.nih.gov/10812937/


Fasinu P, Choonara Y, Khan R, Du Toit L C, Kumar P, Ndesendo V, Pillay V. Flavonoids and Polymer Derivatives as CYP3A4 Inhibitors for Improved Oral Drug Bioavailability. J Pharm Sci . 2013 Feb;102(2):541-55.   https://www.semanticscholar.org/paper/Flavonoids-and-polymer-derivatives-as-CYP3A4-for-Fasinu-Choonara/f864b48f29cc8abe610cc8f7b6300202ad4d4300


Wadhwa S, Singhal S, Rawat S. Bioavailability Enhancement by Piperine: AReview.Asian J Biomed & Pharm Sciences. Vol 4, Issue 36, 2014.   https://www.alliedacademies.org/abstract/bioavailability-enhancement-by-piperine-a-review-5121.html


*These statements have not been evaluated by the FDA. This product is not intended to treat, diagnose, or cure any disease. Consult your personal medical professional before use.


Sleep, Pain, Immune

https://finchannel.com/radicle-science-and-open-book-extracts-release-results-of-the-largest-ever-blinded-randomized-clinical-trial-on-cannabinoids-and-pain/ 


https://journals.sagepub.com/doi/abs/10.1177/17151635221089617#.YmGO0n9SUBk.linkedin


Δ9-Tetrahydrocannabivarin (THCV): a commentary on potential therapeutic benefit for the management of obesity and diabetes  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819335/pdf/42238_2020_Article_16.pdf


Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study  https://pubmed.ncbi.nlm.nih.gov/27573936/ 


Wellness

Opiate reduction with cannabis 2017 by Dr. Burchman   https://journals.sagepub.com/doi/abs/10.1177/0269881117699616 


Use of Cannabis to Relieve Pain and Promote Sleep by Customers at an Adult Use Dispensary  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823130/ 


HHC

HHC and tumors: https://pubmed.ncbi.nlm.nih.gov/?term=Hexahydrocannabinol+tumor 


PATIENT FEEDBACK - RWO

 https://archive.ph/1aq0L


Resources

1. https://pubmed.ncbi.nlm.nih.gov/29302228/  

2. https://www.safeaccessnow.org/

3. http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=292  


Copyright © 1978-2022 CBD Philman, CenedellaUSA, ITALwaterUSA, StopSlavery2011 - All Rights Reserved. In case you're asked, ITAL Water contains less than 0.05% thc, far below legal threshold of 0.3%.  All questions, comments, or results are welcomed at philman@italwaterusa.com or by calling 888.206.3264     peace, Philman          #italwater

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